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Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 265-275 doi: 10.1007/s11705-014-1442-x
关键词: nanotechnology nanomedicine drug delivery therapeutic target delivery
人工智能在药学领域中的应用 Review
路明坤, 殷佳依, 朱奇, 林高乐, 牟敏杰, 柳扶摇, 潘子祺, 游楠欣, 廉希晨, 李丰成, 张洪宁, 郑玲燕, 张维, 张瀚毓, 沈子豪, 顾臻, 李洪林, 朱峰
《工程(英文)》 2023年 第27卷 第8期 页码 37-69 doi: 10.1016/j.eng.2023.01.014
药物研发影响着人类健康的方方面面,并对医药市场有着巨大的影响。然而,由于药物研发(research and development, R&D)过程漫长而复杂,对新药的投资往往收效甚微。随着实验技术和计算机硬件的发展,人工智能(artificial intelligence, AI)近些年来已成为分析大量高维数据的主要工具。生物医学数据规模的爆炸式增长更使得AI得以应用在药物研发的各个阶段。在生物医学大数据的推动下,AI能够更高效、更低成本地发现新药,从而引发了一场药物研发范式的革命。本综述首先简要介绍了药物发现领域常见的人工智能模型,然后总结并深入讨论了这些模型在药物研发各个阶段的具体应用,如靶点发现、药物发现和设计、临床前研究、药物智能制造以及对医药市场的影响。最后,充分讨论了AI在药物研发中的主要局限性,并提出了可能的解决方案。
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 46-53 doi: 10.1007/s11684-010-0010-0
关键词: mitogen-activated protein kinase drug target inhibitor signal transduction disease
Taking advantage of drug resistance, a new approach in the war on cancer
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
关键词: cancer drug resistance genetic screens senescence targeted therapy
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 116-122 doi: 10.1007/s11705-013-1310-0
关键词: psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation
Protein microspheres for pulmonary drug delivery
Yongda SUN,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 82-86 doi: 10.1007/s11705-009-0307-1
关键词: advanced engineering improved pressure aqueous technique
Semi-solid materials for controlled release drug formulation: current status and future prospects
Michelle TRAN,Chun WANG
《化学科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 225-232 doi: 10.1007/s11705-014-1429-7
关键词: controlled release drug delivery semi-solids polymer excipient
Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 246-252 doi: 10.1007/s11705-012-1299-9
Prevalence of antifolate drug resistance markers in in China
《医学前沿(英文)》 2022年 第16卷 第1期 页码 83-92 doi: 10.1007/s11684-021-0894-x
关键词: drug resistance antifolates molecular markers Plasmodium vivax China
Clinical analysis of 275 cases of acute drug-induced liver disease
LI Lei, JIANG Wei, WANG Jiyao
《医学前沿(英文)》 2007年 第1卷 第1期 页码 58-61 doi: 10.1007/s11684-007-0012-8
Zhijian CHEN, Wei LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 1-1 doi: 10.1007/s11705-009-0306-2
Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 483-489 doi: 10.1007/s11705-022-2227-2
关键词: bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch
Engineering platelet-mimicking drug delivery vehicles
Quanyin Hu, Hunter N. Bomba, Zhen Gu
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 624-632 doi: 10.1007/s11705-017-1614-6
关键词: drug delivery platelets nanomedicine bio-inspired biomimetic
Nanocrystal technology for drug formulation and delivery
Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG
《化学科学与工程前沿(英文)》 2015年 第9卷 第1期 页码 1-14 doi: 10.1007/s11705-015-1509-3
关键词: drug nanocrystal nanotechnology formulation bioavailability stabilizers drug delivery
Detection of AmpC β-lactamase and drug resistance of
Rong WANG, Shangwei WU, Xue LI, Ping HE, Yunde LIU
《医学前沿(英文)》 2009年 第3卷 第1期 页码 72-75 doi: 10.1007/s11684-009-0004-y
标题 作者 时间 类型 操作
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
期刊论文
人工智能在药学领域中的应用
路明坤, 殷佳依, 朱奇, 林高乐, 牟敏杰, 柳扶摇, 潘子祺, 游楠欣, 廉希晨, 李丰成, 张洪宁, 郑玲燕, 张维, 张瀚毓, 沈子豪, 顾臻, 李洪林, 朱峰
期刊论文
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
期刊论文
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
期刊论文
Semi-solid materials for controlled release drug formulation: current status and future prospects
Michelle TRAN,Chun WANG
期刊论文
Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery
Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG
期刊论文
Clinical analysis of 275 cases of acute drug-induced liver disease
LI Lei, JIANG Wei, WANG Jiyao
期刊论文
Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery
Zhijian CHEN, Wei LI,
期刊论文
Nanocrystal technology for drug formulation and delivery
Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG
期刊论文